Mixture models for protein structure ensembles
نویسندگان
چکیده
منابع مشابه
Mixture models for protein structure ensembles
MOTIVATION Protein structure ensembles provide important insight into the dynamics and function of a protein and contain information that is not captured with a single static structure. However, it is not clear a priori to what extent the variability within an ensemble is caused by internal structural changes. Additional variability results from overall translations and rotations of the molecul...
متن کاملA Mixture Model for Clustering Ensembles
Clustering ensembles have emerged as a powerful method for improving both the robustness and the stability of unsupervised classification solutions. However, finding a consensus clustering from multiple partitions is a difficult problem that can be approached from graph-based, combinatorial or statistical perspectives. We offer a probabilistic model of consensus using a finite mixture of multin...
متن کاملModel Selection for Mixture Models Using Perfect Sample
We have considered a perfect sample method for model selection of finite mixture models with either known (fixed) or unknown number of components which can be applied in the most general setting with assumptions on the relation between the rival models and the true distribution. It is, both, one or neither to be well-specified or mis-specified, they may be nested or non-nested. We consider mixt...
متن کاملInternal Structure Features of Asphalt Mixture for Field Samples
Asphalt mixture is heterogeneous in nature; therefore, macroscopic parameters alone cannot describe the mechanical behavior of the mixture. In recent years, the arrangement of the aggregate particles in terms of spatial and directional distributions, and contact points are considered as the internal structure of asphalt. The main purpose of this paper is to investigate the microstructural chara...
متن کاملComplementarity of structure ensembles in protein-protein binding.
Protein-protein association is often accompanied by changes in receptor and ligand structure. This interplay between protein flexibility and protein-protein recognition is currently the largest obstacle both to our understanding of and to the reliable prediction of protein complexes. We performed two sets of molecular dynamics simulations for the unbound receptor and ligand structures of 17 pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btn396